Endocrine Abstracts

Background: Insulin-induced hypoglycemia has been demonstrated to prolong the corrected QT (QTc) interval. Prolongation of QTc interval, especially in diabetic patients using insulin, can cause fatal ventricular arrhythmias. The aim of this study was to evaluate the effects of metoprolol, diltiazem and pilocarpine on hypoglycemia-induced QTc prolongation.Methods: Thirty rats were randomly distributed into the following five groups: Group 1 (1 ml/kg salin...

Introduction: Graves’ ophthalmopathy (GO) may develop nearly 25–50% in Graves’ Disease (GD). Clinical manifestations of GO are caused by the over compression of orbital tissues within the restricted orbital bone cavity. Impaired ocular blood flow may disrupt the retinal microstructure and functions. Early recognition of retinal and choroidal changes may alert the physicians for preventing ocular complications of GO. In this study we aimed to investigate the macu...

Objective: Recently, radioablation has been offered for patients with thyroid microcarcinoma, however some authors favor just follow-up as the prognosis of this disease is excellent. In this study, we compared the long-term follow-up results, for a period of 16 years, in patients with thyroid microcarcinoma in a group of patients with thyroidectomy only and in another both thyrodectomized and radioablated.Methods: Two hundred sixty five patients with a p...

Objective: To compare the impact of 4 surgical procedures (mini gastric bypass [MGB], sleeve gastrectomy [SG], ileal transposition [IT], and transit bipartition [TB]) versus medical management on gut peptide secretion, beta cell function, and resolution of hyperglycaemia in type 2 diabetes (T2DM).Research design and methodsA mixed-meal tolerance test (MMTT) was administered 6–24 months after each surgical procedure (mini gast...

Purpose: To determine the changes of the choroidal thickness (CT) in diabetes mellitus (DM) type 1 patients without clinical diabetic retinopathy (DR).Methods: We evaulated 50 patients with DM type 1 (50 eyes) and 50 healthy controls (50 eyes) in İzmir Military Hospital from January 2012, through January 2013. DR status was evaluated by indirect fundoscopy and included the study if they have no clinical diabetic retinopathy. Age, gender, duration s...

Background: Type 2 diabetes mellitus became a global problem during recent decades, and unfortunately medical treatment fails to provide adequate control in many obese diabetics. We aimed to perform a prospective comparative cohort study to investigate how soon patients achieve glycemic control after three different surgical options (sleeve gastrectomy (SG), mini-gastric bypass (MGB), diverted sleeve gastrectomy with ileal transposition (DSIT)) within the first 30 days postope...

Aim: In the present study, we aimed to analyze the incidence of diabetic neuropathy (DN) via electrophysiological testing of type 2 diabetes mellitus (T2DM) patients scheduled for laparoscopic diverted sleeve gastrectomy with ileal transposition (DSIT). At a mean of 8 months after surgery, the electrophysiological tests were repeated and differences in electrophysiological parameters were evaluated to investigate the effects of the operation on outcomes related to diabetic neu...

Background: Medical treatment fails to provide adequate control for many obese patients with type 2 diabetes mellitus (T2DM). A comparative observational study of bariatric procedures was performed to investigate the time at which patients achieve glycemic control within the first 30 postoperative days following sleeve gastrectomy (SG), mini-gastric bypass (MGB), and diverted sleeve gastrectomy with ileal transposition (DSIT).Methods: Included patients h...

Background: Treatment of vitamin D deficiency orinappropriate vitamin D supplementation may cause side effects associated with hypercalcemia. We observed a tendency to use very high single dose cholecalciferol for treatment of vitamin D deficiency.Aim: The primary aim of this study was to examine the clinical characteristics of patientswith very high serum 25OHD levels of vitamin D toxicity in Turkey.Materials and methods: An invit...